Lipoprotein-associated phospholipase A2 (Lp-PLA2)

Lp-PLA2 protein (Datasheet)

Description	Lp-PLA2 protein (48.6 kD) with His-tag, cultured in vitro
Applications	Calibrator and quality control product
Catalog number	K2956
Source	Mammalian cell
Purity	>90% as analysized by SDS-PAGE
Buffer	50mMNaAc, 150 mM NaCl, 10% Glycerol, pH5.0
Storage instructions	Store at - 80°C (– 112°F) for up to 3 years.
Sequence	FDWQYINPVA HMKSSAWVNK IQVLMAAASF GQTKIPRGNG PYSVGCTDLM FDHTNKGTFL RLYYPSQDND RLDTLWIPNK EYFWGLSKFL GTHWLMGNIL RLLFGSMTTP ANWNSPLRPG EKYPLVVFSH GLGAFRTLYS AIGIDLASHG FIVAAVEHRD RSASATYYFK DQSAAEIGDK SWLYLRTLKQ EEETHIRNEQ VRQRAKECSQ ALSLILDIDH GKPVKNALDL KFDMEQLKDS IDREKIAVIG HSFGGATVIQ TLSEDQRFRC GIALDAWMFP LGDEVYSRIP QPLFFINSEY FQYPANIIKM KKCYSPDKER KMITIRGSVH QNFADFTFAT GKIIGHMLKL KGDIDSNVAI DLSNKASLAF LQKHLGLHKD FDQWDCLIEG DDENLIPGTN INTTNQHIML QNSSGIEKYN HHHHHH
SDS-PAGE

Description

Lipoprotein-associated phospholipase A2 (Lp-PLA2) is produced by inflammatory cells and circulates primarily bound to low-density lipoprotein (LDL) and is to a lesser extent associated with high-density lipoprotein (HDL) in human plasma. LDL oxidation is known as an early key event in the pathogenesis of atherosclerosis. Elevated Lp-PLA2 levels have been found in atherosclerotic plaques and rupture lesions.

Serum Lp-PLA2 level has higher sensitivity in predicting the vulnerability of the coronary atherosclerotic plaque than hs-CRP. In combination with hs-CRP, Lp-PLA2 is considered as a new biomarker to predict the presence of vulnerable plaque and vascular dysfunction.

Results are given in nanograms per milliliter (ng/mL). The normal range for Lp-PLA2 is less than 200 ng/mL.

Lipoprotein-associated phospholipase A2 (Lp-PLA2)

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