Kidney Injury Molecule 1 (KIM-1)
| Description |
KIM-1 protein with His-tag, cultured in vitro |
| Applications |
Calibrator and quality control product |
| Catalog number |
K5956 |
| Source |
Mammalian cell |
| Purity |
>90% as analysized by SDS-PAGE |
| Buffer |
1 x PBS，pH 7.4 |
| Storage instructions |
Store at - 80°C (– 112°F) for up to 3 years. |
Description
Kidney Injury Molecule-1 (KIM-1) is a type 1 transmembrane gly?coprotein with an immunoglobulin-like and mucin domain. It is expressed on the surface of tubular epi-thelial cells in the kidney.
KIM-1 levels are unde?tectable in normal kidneys, whereas elevated KIM-1 expression was detected in the ischemic kidney of patients. KIM-1 concentration in the urine of healthy humans is less than 1 ng/ml. Meanwhile, following the ischemic kidney injury it could be elevated up to 3-7 ng/ml. KIM-1 levels begin to increase as early as 6 hours after an ischemic insult and remain elevated for a period of 48 hours post-injury. Due to its simplicity and high specificity, KIM-1 may serve as a biomarker for renal proximal tubule injury facilitating the early diagnosis of the disease and serving as a diagnostic discriminator.
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